Chemical 4-Hydroxypyridine Product Usage

Press Release : August 07, 2020
Chemical 4-Hydroxypyridine Product Usage

Chemical 4-Hydroxypyridine Description
Beige crystalline powder

Chemical 4-Hydroxypyridine Basic Attributes
CAS No:626-64-2

Molecular Formula :C5H5NO

Molecular Mass :95.1

Exact Mass :95.037117

PSA :29.1 A^2

LogP :-1.3

EINECS :210-958-3

InChIKeys :GCNTZFIIOFTKIY-UHFFFAOYSA-N

H-bond Acceptor :2

H-bond Donor :1

SP3 :0.00

RBN :0

Chemical 4-Hydroxypyridine Characteristics
Appearance :Beige to light brown Powder or Chunks

Density :1.2±0.1 g/cm3

Melting Point :150-151 °C(lit.)

Bolling Point :230-235 °C12 mm Hg(lit.)

Flash Point :221 °C

Refractive Index :1.560

Solubility :H2O: soluble

BRN :105800

Chemical 4-Hydroxypyridine Safety Information
Hazard Class :IRRITANT

HS Code :2933399090

UN No. :NONH for all modes of transport

WGK_Germany :3

Risk Code :36/37/38-41-37/38-22

Safety Instructions :26-36-37/39-39

RTECS No. :UU7701450

Dangerous Mark :Xi,Xn

P Code :P261-P280-P305 + P351 + P338

Hazard Statements :H302-H315-H318-H335

Hazard Note :Harmful/Irritant

Chemical 4-Hydroxypyridine Product Usage
Used in the synthesis of diuretic drug torasemide or other drug intermediates

Chemical 4-Hydroxypyridine Production Methods
General procedure: In a typical reaction, 10 molpercent CuSO4·5H2O, (0.049 g, 0.2 mmol)and 6.7 molpercent EA (20 mg) were mixed in methanol followed by2 mmol of phenylboronic acid. This reaction mixture was kept ina preheated oil bath by maintaining the temperature at 60 °C andstirred under atmospheric pressure. After completion of the reac-tion, modified by TLC, the mixture was washed twice with hot ethylacetate to remove the reactant and product. The hot ethyl acetatewas removed from the reaction mixture and the resulting crudeproduct was purified by a column chromatography using silicagel 260 mesh (pet ether:ethyl acetate) ratio (25:75). The recov-ered catalyst was reused for the next run. All the products werecharacterized by1H and13C NMR spectra.General procedure: To a solution of [2-(phenoxy)-ethyl]-trimethyl-silane (Table-3, entry-1) (195mg, 1.0 mmol) in dry DMF (2 ml) was added cesium fluoride (576 mg, 3.0 mmol) and heated at 60°C for 1 h. Reaction mass was diluted with water and extracted with ethyl acetate (3 x 20 ml). The combined organic layer was washed with water, brine solution, dried over anhydrous sodium sulphate and concentrated under reduce pressure to give phenol 92mg (93percent yield). Phenols of Table-3 are commercially available from Aldrich and its identity was confirmed by comparison of 1H NMR data with authentic sample.General procedure: In a typical experiment, benzyl 4-methoxyphenyl carbamate (1a, 1 mmol) and 10 cm

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